Protein Modification Reagents
Medchemexpress LLC DBCO-PEG4-Desthiobiotin | 2032788-37-5 | 96.4% | C39H53N5O8 | 25 MG
DBCO-PEG4-Desthiobiotin is a PEG-based PROTAC linker used in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide groups
- For research use only
Medchemexpress LLC Fmoc-NH-PEG5-CH2COOH | 635287-26-2 | MFCD26142982 | >97.0% | 517.57 g/mol | C27H35NO9 | 50 MG
Fmoc-NH-PEG5-CH2COOH is an Fmoc-protected PEG5 linker bearing a terminal carboxylic acid, supplied for research use and commonly used as a cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PEG-based PROTAC linker.
- Fmoc-protected amine with a terminal carboxyl functional group.
- Peg5 spacer providing flexible, hydrophilic linkage.
- Purity greater than or equal to 97.0%.
- Molecular weight 517.57 g/mol.
- CAS number 635287-26-2 for unambiguous identification.
- Available in small-scale quantities; confirm specific pack size with supplier.
eMolecules 2567199-52-2 | Bis-PEG25-TFP ester | Broadpharm | MFCD21363296 | 1515.532 | C66H106F8O29 | 97.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)Oc2c(F)c(F)cc(F)c2F)c1F | 100mg | 229582525
Bis-PEG25-TFP ester | Broadpharm | 2567199-52-2 | MFCD21363296 | 1515.532 | C66H106F8O29 | 97.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)Oc2c(F)c(F)cc(F)c2F)c1F | 100mg | 229582525
Medchemexpress LLC 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane | 55400-73-2 | 95.0% | 350.41 | 1 G
Ms-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC DBCO-mPEG | 00-00-0 | 98.4% | 10MG
DBCO-mPEG is a DBCO-functionalized methoxy-polyethylene glycol (mPEG) reagent with an average molecular weight of 5,000 Da. Supplied as a white to light yellow solid for research use, it enables copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) to conjugate azide-containing molecules and serves as a spacer or linker in bioconjugation and PROTAC synthesis.
- Enables copper-free click chemistry (SPAAC) with azide-containing partners.
- Provides a methoxy-terminated PEG spacer with average MW 5,000 Da.
- Supplied as a solid with high reported purity (~98.4%).
- Suitable for bioconjugation, linker construction, and PROTAC applications.
- Stable when stored at -20°C under inert atmosphere; in solution, store at -80°C for long-term.
Medchemexpress LLC m-PEG24-NHS ester | 2395839-96-8 | 99.9% | 100 MG
m-PEG24-NHS ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This compound has a molecular weight of 1214.39 and the chemical formula C54H103NO28, appearing as a white to off-white solid.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- High purity of 99.9%
- White to off-white solid appearance
Medchemexpress LLC 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane | 55400-73-2 | 95.0% | 350.41 | 5 G
Ms-PEG4-MS is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for a target protein.
- PEG-based linker for PROTAC synthesis
- Facilitates targeted protein degradation via the ubiquitin-proteasome system
- Available in various quantities for research needs
Cayman Chemical dPE-PEG 2000-NHS 50mg
A PEGylated derivative of DSPE; has been used in the generation of micelles and in combination with other lipids in the formation of liposomes; intravenous injection of liposomes containing DSPE-PEG(2000)-NHS ester localize to mouse liver and tumor tissue; liposomes containing DSPE-PEG(2000)-NHS ester conjugated to H6 peptide and encapsulating doxorubicin reduce tumor growth in an SK-BR-3 breast cancer mouse xenograft model
eMolecules Medchem Express | DSPE-PEG6-Mal | 25mg | 722714234 | HY-138395 | 1163.519 | C60H111N2O17P
Medchem Express | DSPE-PEG6-Mal | 25mg | 722714234 | HY-138395 | | 1163.519 | C60H111N2O17P
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 250 MG
DBCO-PEG4-DBCO is a versatile PEG-based PROTAC linker and a cleavable ADC linker. It is utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Used in PROTAC synthesis
- Cleavable ADC linker
- Click chemistry reagent
- Features a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide groups
eMolecules 203740-63-0 | Propargyl-PEG3-bromide | Broadpharm | MFCD28505517 | 251.120 | C9H15BrO3 | 98.000 | BrCCOCCOCCOCC#C | 1g | 279709416
Propargyl-PEG3-bromide | Broadpharm | 203740-63-0 | MFCD28505517 | 251.120 | C9H15BrO3 | 98.000 | BrCCOCCOCCOCC#C | 1g | 279709416
Cayman Chemical ANTIBODY DBCO acId 500mg
A copper-free click chemistry reagent; has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro; has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to induce cytotoxicity and reduce tumor growth, respectively
Medchemexpress LLC TCO-PEG2-amine | 2141981-87-3 | ≥97.0% | C15H28N2O4 | 25 MG
TCO-PEG2-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to degrade target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker, leveraging the intracellular ubiquitin-proteasome system. This product appears as a colorless to light yellow liquid.
- PEG-based PROTAC linker
- Suitable for the synthesis of PROTACs
- Purity ≥97.0%
- Colorless to light yellow liquid appearance
- For research use only